Tīmeklis哺乳动物 Rac 有三个序列高度相似的同工型（Rac1、Rac2 和 Rac3）。特征明显的 Rac1 和 cdc42 普遍表达，并在细胞骨架重组、膜转运、转录调节、细胞生长和发育 … TīmeklisTakenaka, N., Izawa, R., Wu, J., Kitagawa, K., Nihata, Y., Hosooka, T., … Satoh, T. (2014). A critical role of the small GTPase Rac1 in Akt2-mediated GLUT4 ...

FXR1 regulates vascular smooth muscle cell cytoskeleton, VSMC ...

Rac1 is a small (~21 kDa) signaling G protein (more specifically a GTPase), and is a member of the Rac subfamily of the family Rho family of GTPases. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of GLUT4 translocation to glucose uptake, cell growth, … Skatīt vairāk Rac1, also known as Ras-related C3 botulinum toxin substrate 1, is a protein found in human cells. It is encoded by the RAC1 gene. This gene can produce a variety of alternatively spliced versions of the Rac1 … Skatīt vairāk Along with other subfamily of Rac and Rho proteins, they exert an important regulatory role specifically in cell motility and cell growth. Rac1 has ubiquitous tissue expression, and drives cell motility by formation of lamellipodia. In order for cancer cells to … Skatīt vairāk RAC1 has been shown to interact with: • ARFIP2, • ARHGDIA, • BAIAP2, Skatīt vairāk • Benitah SA, Frye M, Glogauer M, Watt FM (Aug 2005). "Stem cell depletion through epidermal deletion of Rac1". Science. 309 (5736): 933–5. Bibcode:2005Sci...309..933A. doi:10.1126/science.1113579. PMID 16081735. Skatīt vairāk Rac1 is expressed in significant amounts in insulin sensitive tissues, such as adipose tissue and skeletal muscle. Here Rac1 regulated … Skatīt vairāk Activating mutations in Rac1 have been recently discovered in large-scale genomic studies involving melanoma and non-small cell lung cancer. As a result, Rac1 is considered a therapeutic target for many of these diseases. A few recent … Skatīt vairāk • rac1+GTP-Binding+Protein at the U.S. National Library of Medicine Medical Subject Headings (MeSH) • RAC1 Info with links in the Cell Migration Gateway Archived 2014-12-11 at the Wayback Machine Skatīt vairāk TīmeklisThe GTPases belonging to the Rho family control the actin cytoskeleton rearrangements needed for particle internalization during phagocytosis. ROCK and mDia1 are downstream effectors of RhoA, a GTPase involved in that process. Coxiella burnetii, the etiologic agent of Q fever, is internalized by the host´s cells in an actin-dependent … lavender the movie cast

Rac1 GTPase in rodent kidneys is essential for salt-sensitive ...

Tīmeklis1992. gada 1. jūn. · Rac1, a member of the family of low-molecular-mass GTP-binding proteins, functions in phagocytic leukocytes as a component necessary for activation … TīmeklisRac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages (By similarity). ... It is able to bind to the GTPase-binding domain of PAK but not full-length PAK in a GTP-dependent manner, suggesting that the insertion does not completely ... TīmeklisMuscle Cell Migration by Suppressing Small GTPase Rac1 Activation Dong Liu, Jie Hou, Xing Hu, Xuerong Wang, Yan Xiao, Yongshan Mou, Hector De Leon Abstract—The Slits are secreted proteins with roles in axonal guidance and leukocyte migration. On binding to Robo receptors, Slit2 repels developing axons and inhibits … lavender therapy