WebApr 7, 2024 · Perurena et al. show that PDACs are resistant to MEK inhibitors because they trigger the formation of USP9X:Mcl-1 complexes, thereby acutely stabilizing Mcl-1 and inhibiting apoptosis. Resistance can be overcome by targeting Mcl-1 with direct inhibitors or by suppressing Mcl-1 transcription with CDK inhibitors, revealing new therapeutic … http://mcrhrdi.gov.in/dr2024/week3/9-PubFin-GFR-March2024.pdf

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WebApr 14, 2024 · Introduction. Chronic kidney disease (CKD) defined as “kidney damage or glomerular filtration rate (GFR) <60 ml/min/1.73 m 2 for three months or more, irrespective of cause” is a global public health problem [].In 2024, it was estimated that 9.1% of the world population had CKD and 1.2 million deaths were attributed to it [].It is important to … Web1 day ago · Gaglia et al. find striking changes in the spatial arrangement of immune cells in response to tumor antigens. T and B cells are recruited in lymphocyte networks (“lymphonets”), which contain progenitor T cells. After immunotherapy, lymphonets gain cytotoxic T cells, likely due to progenitor cell differentiation and activation in this distinct … Web他汀与造影剂肾病：一箭双雕,造影剂肾病(CIN)：常用定义,尚无统一的定义，但一般造影剂肾病指： 在无其他明确原因的情况下，在使用造影剂后2-7天，血清肌酐升高超过25%，或绝对升高0.5 mg/dl copywriting crew