WebOct 18, 2024 · What happens when your C4 level is low? C4 is involved in immune tolerance. When there is a lack of C4, the immune system may start reacting against the body’s own cells. Researchers think that low C4 levels increase the risk of developing an autoimmune disease, such as lupus and juvenile idiopathic arthritis [ 35 ]. ... WebIf C4 is low, the subsequent measurement of antigenic and functional C1-INH levels confirms the diagnosis and distinguishes between type I and type II hereditary angioedema. If C4 and C1-INH levels are normal, consider …
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WebThose that cause complement consumption (and therefore low C3 and low C4, if not overwhelmed by compensatory increased liver production of C3 and C4) include SLE, antiphospholipid syndrome, mixed cryoglobulinemia, Sjögren syndrome, and membranoproliferative glomerulonephritis. Since these all can consume complement, … WebLow Complement Levels. ... For example, lower levels of C3 and C4 are a sign of lupus. Decreased complement activity may also be due to the following conditions: Cirrhosis; … WebDec 2, 2024 · - Acquired causes of low C3 and C4 and total hemolytic complement; RELATED TOPICS. Acquired C1 inhibitor deficiency: Clinical manifestations, … incontinence machine manufacturer