WebMay 3, 2024 · Susceptibility of patients to antibiotic-associated C. difficile disease is intimately associated with specific changes to gut microbiome composition. In particular, loss of microbes that modify bile salt acids (BSA) play a central role; primary bile acids stimulate spore germination whilst secondary bile acids limit C. difficile vegetative growth. To … WebApr 13, 2024 · Fecal microbiota transplantation (FMT) has been extensively studied since its approval for treating human Clostridium difficile infections (CDI) by the US Food and Drug Administration in 2013 . ... which may prevent the growth and germination of C. difficile spores both in vitro and in vivo [41,42]. In summary, while multiple factors contribute ...
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WebObjective Faecal microbiota transplant (FMT) effectively treats recurrent Clostridioides difficile infection (rCDI), but its mechanisms of action remain poorly defined. Certain bile acids affect C. difficile germination or vegetative growth. We hypothesised that loss of gut microbiota-derived bile salt hydrolases (BSHs) predisposes to CDI by perturbing gut bile … WebClostridium difficile is a major cause of intestinal infection and diarrhoea in individuals following antibiotic treatment. Recent studies have begun to elucidate the mechanisms that induce spore formation and germination and have determined the roles of C. difficile toxins in disease pathogenesis. Exciting progress has also been made in defining the role of … tous packaging
Clostridium difficile spore germination: an update - PubMed
WebMar 4, 2024 · Other strategies restore a C. difficile-resistant gut microbiota.While FMTs are undefined in their microbial composition, recent work has focused on identifying and generating specific bacteria or … Webthat C. diff is found in the colons of 2-5% of the healthy adult population. However, the gut flora of humans tends to prevent extensive germination of C. diff spores and the resulting extensive invasion of C. diff colonies. Some humans have C. diff bacteria that have germinated to form some bacterial colonies, but infection and symptoms do not ... WebAug 1, 2016 · Clostridium difficile history in humans PMC: pseudomembranous colitis. Since then, the number of reports documenting C. ... The medium includes egg-yolk or blood and taurocholate, desoxycholate or cholate, which has been shown to induce germination of spores. Presently, several commercial selective media are available. ... tous ph